For the RAI radio, De Santis appeared in many roles, mainly in the serials Barocco a Roma and Racconto Italiano which were broadcasted in the late 1970s. In the 1989 she began working in the international broadcasting department were she produced Notturno Italiano , AZ per gli Italiani all'Estero, Italia Canta, Itinerari Italiani, Facile Ascolto.

In 1997 and 1998 she produced the radio show L'Arca di Noè.
In 1998, for Rai International she produced Ciak si esegue,13 episodes about Italian cinema soundtracks. In 1999, for "Radio Due" she developed and produced a program devoted to animals, L'Anello di Re Salomone. Since 2002, she has occasionally directed an entertainment program, Due di Notte.